the study isn’t open access, I’m pretty sure nobody has read the study including the nature “article” author.

it’s pretty bad form, and intellectually dishonest, to share a paywalled article on a paywalled paper, just because you like the title… ensuring nobody will read what is actually said is pretty anti-science.

6% from soybean oil, total energy from fat was about 80%, except they didn’t count fibre in the diet as carbohydrates… if you do that its a 15% carb diet.

also 50g of fibre in the feed diet, maybe the tumors are responding to fibre?

i’m just skimming right now, but the papers studies each used 2-4 mice, and are not powered at all. it’s hard to say even if you WERE a PPAR-CPT1A engineered mouse that these results are relevant… they knocked out ketogenesis in a few of the mice and still saw tumor growth… let’s not forget the genetic engineering here not only induces tumors, but also suppresses bhb production… so maybe these tumors respond well to fatty acids, but would be suppressed by healthy bhb production and ketone metabolism… this paper doesn’t know. it’s possible the net effect of a healthy ketogenic metabolism would be enough in non-genetically engineered mice to reduce the tumors… they didn’t test that.

plus… they didn’t measure all cause mortality! so we just know tumor growth for a window… why not actually get all cause mortality data? nothing ruins short term results like long term data.

the fact we have human interventional studies directly linking tumor growth to glucose intake, and in this mice study we see the opposite only in their genetically engineered tumors… i’m not sure we can make any meaningful conclusions from that.

What were the mice fed? Is this like a vegetarian low carb diet where the fats come from factory fats - seed oils?

this was the diet used https://researchdiets.com/en/formulas/d06040601 sucrose, corn starch, soybean oil, food dyes… you know… keto stuff… 6% daily energy from soybean oil

Were they also fed carcinogens?

the mice were genetically engineered to develop tumors, so not fed, designed.

There is reason to think that high meat, high animal fat diets are protective against cancer, as cancer depends on sugar

This study isn’t about keto, its about the pathway of tumor growth in genetically engineered tumor laden mice in a high fat diet… unless your a mouse engineered to develop tumors genetically this doesn’t apply to you.

Tire dust

I hate click bait